The Greenland Ice Sheet (GIS) is currently a topic of much interest because of its important, but unknown, response to future climate change. Projections of future GIS behavior are uncertain in part because we do not know how fast its outlet glaciers can retreat under rapidly warming conditions. This limits our ability to foresee how fast GIS outlet glaciers will retreat. In our research on Baffin Island we attempt to shed light on the potential future response of the GIS by documenting Laurentide Ice Sheet (LIS) retreat during a past warmer-than-present interval. Here we document the deglaciation of the LIS outlet glacier that occupied Sam Ford Fiord, NE Baffin Island, during the early Holocene. The early Holocene period on Baffin was marked by the Holocene Thermal Maximum (~10 to 7 ka), when summer temperatures were nearly 5°C warmer than historic summer temperatures. This early Holocene period of warmth was interrupted by abrupt cold spells, the best known of which is the 8.2 ka cooling event. The Cockburn moraine complex (~9 ka), which spans Baffin Island’s NE margin near the heads of most fiords, provides direct evidence that the retreat of the LIS across Baffin Island’s NE coast was interrupted by readvances during the early Holocene. It is unknown, however, whether the LIS was responding to abrupt regional climate shifts, or whether the outlet glaciers within the fiords were responding instead to topographic constraints related to fiord geometry. We employ 10Be and radiocarbon dating to constrain the timing and pattern of early Holocene deglaciation of a ~115-km-long transect from the mouth to the head of Sam Ford Fiord. We sampled 19 striated bedrock sites for 10Be exposure dating, and marine bivalves from 5 raised marine delta sites for radiocarbon dating. Preliminary ages suggest that ice still extended to the fiord mouth as late as ~9.0 ka, and that the bulk of the deglaciation was fairly rapid, retreating approximately 100 km in 1000 years or less. In the inner fiord, ages imply that the retreat of the outlet glacier was slower in the next 1000 years. The presence of numerous lateral and end moraines suggests that this edge of the LIS was fluctuating between ~8 and ~7 ka. Both radiocarbon and 10Be ages imply that the fiord head was not ice free until ~6.5 ka. Pending ages should add yet more resolution to the early Holocene retreat within Sam Ford Fiord.